HLA-C and neoplasm: They include alteration of the features of the tumor cells themselves (up-regulation of anti-apoptotic molecules and of cytotoxic determinants and downregulation of antigen presentation MHC molecules), secretion of cytokines that inhibit effective immune response (e.g., VEGF, IL-10, and TGFβ), and the induction of an immuno suppressive environment by indoleamine 2,3 dioxygenase (IDO) or via recruitment of inhibitory immune cells (Treg, MDSC, NKT, iDC, and macrophages) [4–6].