To summarize, the development of skin lesions in DH could depend upon an ongoing mucosal immune response in the gut associated with elevated IL-8 levels and the production of a sufficient local concentration gradient of IL-8 and other chemokines (perhaps as a result of local trauma) that would attract “partially primed neutrophils” to the skin. The gene discussed is CXCL8; the disease is dermatitis herpetiformis, familial.