Many factors may contribute to tumor escape under the immune pressure imposed by therapies, including immunogenicity alterations (downregulation of MHC expression, loss of antigen) in tumor cells in response to therapy, amplification of immunosuppressive cells (Tregs, MDSCs), and induction of immune checkpoint molecules in effector T cells (CTLA-4, PD-1). The gene discussed is HLA-C; the disease is neoplasm.