Troglitazone dramatically reduces cell proliferation of A549 cells, a human lung adenocarcinoma cell line, at concentrations of 10 to 40 μM. Because PPARγ activity, determined by reporter assays, reached a maximal level at 15 μM while the beneficial reductions in cell proliferation continued up to 40 μM, the authors suggested that troglitazone had desirable PPARγ-independent effects at elevated doses [51]. Here, PPARG is linked to lung adenocarcinoma.