The risk allele locate at the intron 2 of the FGFR2 gene (rs2981582) represents 5–10% of breast cancer patients with estrogen receptor (ER)-positive tumor, whereas the SNP rs3803662 of TNRC9 gene seem to be correlated positively with bone metastases and ER-positive breast cancer patients. This evidence concerns the gene TOX3 and breast carcinoma.