NF1 and cancer: We found that NF1 1-1162, the pre-GRD region of neurofibromin indeed alters the expression of genes that participate in cell adhesion and migration, and acts as a negative regulator of the Rac1/Pak1/LIMK1/cofilin pathway [5, 11, 17], a pathway highly involved in cancer [10, 20, 21] (see scheme in Fig. 1).