However, lack of association had been reported for the SNPs at chromosome 2p16.3 [22-24], loci detected in the Japanese GWAS [25], and recently the CYP46A1 [26] and TLR4 genes [27], whereas associations of LMX1B SNPs with POAG have not been replicated in populations other than the initial cohort. This evidence concerns the gene TLR4 and open-angle glaucoma.