CYP46A1 and open-angle glaucoma: Recently, significant associations of variants in the toll-like receptor 4 (TLR4) [17], LIM homeobox transcription factor 1-beta (LMX1B) [18], and cholesterol 24S-hydroxylase (CYP46A1) [19] genes with POAG have been reported in Japanese, British, and French populations, respectively.