Cyclin D1 overexpression is described as a driving molecular event in various types of cancer, including mantle cell lymphoma (MCL), plasmacellular dyscrasia, a subset of cutaneous T cell lymphomas, ,non-small cell lung cancer, and carcinomas of breast, head and neck, and esophagus [12,18-22]. The gene discussed is CCND1; the disease is mantle cell lymphoma.