Given that studies about association between birth-weight and insulin resistance has been developed measuring insulin and glucose levels in adolescence or adulthood and collecting information of birth-weight in a retrospective way, the aim of this study was to determine if the abnormal birth-weight is related with elevated insulin levels and increase of the Homeostasis Model assessment for Insulin Resistance (HOMA-IR) index at birth, in at term newborns. The gene discussed is INS; the disease is Insulin resistance.