In this study, we retrospectively analyzed the data of 92 patients with S-ALCL from a single referral center, the Peking University Lymphoma Center, for clinical features, expression rates of ALK, BCL-2, WT1 and Ki-67, and their association with outcome to determine potential combinations of factors in predicting the prognosis of S-ALCL. The gene discussed is ALK; the disease is anaplastic large cell lymphoma.