About 60% of S-ALCL express anaplastic lymphoma kinase (ALK), a chimeric protein with tyrosine kinase activity that is most commonly created by a unique chromosomal translocation t(2;5)(p23;q35) resulting in the fusion of the ALK gene with the nucleophosmin (NPM) gene [3,4]. Here, NPM1 is linked to anaplastic large cell lymphoma.