In this study, we investigated the association between history of ischemic stroke and polymorphisms of genes encoding prototypical inflammatory molecules, such as interleukin 4 (IL-4), interleukin 6 (IL-6), intercellular adhesion molecule 1 (ICAM-1), E-selectin (E-sel), chemokine (C-C motif) ligand 11 (CCL11), lymphotoxin α (LTA), and so on. Here, IL6 is linked to ischemic stroke.