To explore the influence of inflammatory genes on ischemic stroke in the hypertension and non-hypertension groups, we stratified study subjects by their hypertension status and found that CCR2 rs1799864 and CCR5 rs1799987 polymorphisms were associated with ischemic stroke in the hypertensive group, and CCL11 rs3744508, LTC4S rs730012, FCER1B rs569108, TGFB1 rs1800469 and LTA rs909253 were associated with ischemic stroke in the non-hypertensive group. Here, CCR2 is linked to ischemic stroke.