Furthermore, in several pathological situations, such as acute coronary syndrome and unstable angina [9], polycystic ovary syndrome [36], heart failure [32], human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) [37], CAD patients after positive exercise test [38] and hypertension [39], the Lp-PLA2 activity was increased compared with controls. This evidence concerns the gene PLA2G7 and HIV infectious disease.