Of note, when mice were vaccinated with DCloaded with apoptotic/necrotic B16 cells (DC-Apo/Nec), a tertiary lymphoidstructure was generated at the vaccination site that contained a wide varietyof cell populations, including macrophages, polymorphonuclear cells, as wellas CD4+ and CD8+ T lymphocytes found togetherwith DC [30].This suggests that macrophages could also contribute to the antitumor responseagainst gamma-irradiated tumor cells locally, or after migration to the lymphnodes. Here, CD8A is linked to neoplasm.