CD8+T cells can be stimulated after phagocytosis by a process called cross-presentationthat allows exogenous peptides to be presented in the context of HLA ClassI molecules [20].Some other studies have used non-naturally occurring tumor-associated antigenssuch as tumor cells virally transduced with antigens or apoptotic tumor cellsinfected with recombinant viruses encoding melanoma associated antigens [21]–[24]. This evidence concerns the gene CD8A and neoplasm.