Disruption of the LINC complex via mutations in nesprin-1 and -2 or their binding partners, such as emerin and lamin A/C, give rise to Emery Dreifuss Muscular Dystrophy (EDMD) [6], [10], [11], [12], [13], [14], [15], [16], [17]. Here, SYNE1 is linked to Emery-Dreifuss muscular dystrophy.