IGHE and AIDS: During HIV infection and in humoral immunity context, initial observations revealed that patients with acquired immune deficiency syndrome (AIDS) could exhibit hyperimmunoglobulinemia, increasing expression of cell-activation markers, depletion of memory B cells inducing ineffective recall responses, polyclonal B-cell hyperactivity, and altered differentiation of naïve B cells that could result in impaired immunoglobulin class switch recombination (CSR), and thus production of nonspecific immunoglobulin (Ig)G, IgE and IgA antibodies [3], [4], [5], [6], [7], [8].