Given that the xeroderma pigmentosum (XP) syndromes caused by XP germ-line mutations fit a recessive genetic model, in which heterozygotes are unaffected [62], we tested the hypothesis that the XPF polymorphisms were associated with overall cancer risk, assuming a recessive genetic model (i.e., only the variant homozygous genotype was considered the risk genotype). The gene discussed is ERCC4; the disease is xeroderma pigmentosum.