However, although several previous studies have shown that expression levels of DNMT3b mRNA [8], [9], [39], [40] and protein [13], [40], [41] were increased in a variety of malignant tumors, our current data demonstrated a lower expression of DNMT3b in ovarian cancer tissues compared to that of benign tumor. The gene discussed is DNMT3B; the disease is ovarian carcinoma.