Subsequently, multivariate Cox regression models using clinical stage, tumor size, location of neoplasia, DNMT1 and DNMT3b co-expression revealed that only clinical stage (OS, P = 0.022, RR = 6.977, 95% CI: 1.322∼36.822; DFS, P = 0.026, RR = 4.686, 95% CI: 1.207∼18.196) remained as an independent prognostic factor (Table 6). The gene discussed is DNMT1; the disease is neoplasm.