In summary, taking advantage of the establishment of orthotopically transplanted metastatic mouse model of gastric carcinoma and the knocking down clones of CD97/EGF1,2,5 which showed poor metastatic ability, we demonstrate CD97 small isoform not only supports gastric cancer local growth, but also facilitates metastasis in a mouse model. Here, GFM1 is linked to gastric carcinoma.