ATP13A2 and Parkinson disease: To begin to explore the potential pathogenic effects of missense mutations in ATP13A2 associated with early-onset parkinsonism, we generated expression constructs for V5-tagged human ATP13A2 harboring homozygous (F182L, G504R and G877R) or heterozygous (T12M, G533R and A746T) missense mutations (Figure 1A).