ATP13A2 and Parkinson disease: A number of homozygous (F182L [Japan] [14], G504R [Brazil] [10] and G877R [Italy] [9]) and heterozygous (T12M [Italy] [10], G533R [Italy] [10] and A746T [Taiwan/Singapore] [15]) missense mutations have recently been identified in subjects with early-onset forms of familial or sporadic parkinsonism or Parkinson's disease (PD) suggesting that ATP13A2 mutations may also contribute to early-onset PD.