Despite the broad heterogeneity among CLL samples, our data demonstrated a relationship between HS1 protein expression and prognostic factors: high HS1 expression was associated with lack of IgVH mutations [29], positivity to CD38 [30] and presence of genetic abnormalities such as 17p- and 11q- [31]. The gene discussed is CD38; the disease is B-cell chronic lymphocytic leukemia.