ZC3H12A and Hyperglycemia: It has been recently shown [49] that hyperglycemia-induced expression of MCP-1 and MCP-1-induced protein (MCPIP) leads to ROS production, endoplasmic reticulum stress, autophagy and cardiomyocyte death, thus playing a critical role in the pathophysiological progression of diabetic cardiomyopathy [49].