INSR and muscle tissue disorder: Several interesting pathways and functions were enriched significantly in the DM2 group compared to CTR, such as “Mitochondrial Dysfunctions”, “TGF-β Signaling”, “Insulin Receptor Signaling”, “Calcium Signaling” for the pathways and “Skeletal and Muscular System Development”, “Cell Cycle”, “Cell Death”, “Skeletal and Muscular Disorders” for the enriched functions (Table S2 and S3).