IPA analysis of miRNAs predicted targets differentially modulated in DM2 patients identified several important pathways enriched, such as: “Insulin Receptor Signaling”, “Integrin Signaling”, “PI3K/AKT Signaling” and “TGF-β Signaling” (Table 2 and Table S5). This evidence concerns the gene AKT1 and myotonic dystrophy type 2.