NOTCH1 and acute lymphoblastic leukemia: Notably, serially transplantable CD34+ cells from NOTCH1Mutated (patients 03, 05, 08, 11) and NOTCH1High (patient 02) T-ALL samples showed increased human NOTCH1 (***, P<0.001; **, P<0.01) transcript levels compared to bone marrow engrafted with NOTCH1WT (patient 09) CD34+ T-ALL cells (Figure S1C).