NOTCH1 and acute lymphoblastic leukemia: Although NOTCH1Mutated T-ALL LIC demonstrated enhanced leukemic engraftment capacity compared with NOTCH1WT T-ALL CD34+ cells, the survival of NOTCH1Mutated T-ALL LIC appeared to be reliant on NOTCH1 signaling, thereby leading to enhanced sensitivity to hN1 mAb inhibition in a niche-dependent manner.