While in the present studies, our analyses of the refined LIC marker were focused on the NOTCH1Mutated samples, additional markers, or activation of other receptor-mediated signaling pathways such as insulin-like growth factor 1 receptor [43], may also be informative to determine the leukemic potential of LIC in non-NOTCH1Mutated T-ALL patients. The gene discussed is IGF1R; the disease is acute lymphoblastic leukemia.