To test our hypothesis that the CD2+CD7+ subset of the CD34+ human progenitor population identifies a LIC-enriched population in NOTCH1Mutated T-ALL samples, CD34+CD2+CD7+Lin- cells from NOTCH1Mutated T-ALL samples (Patients 05 and 11) were FACS Aria purified and serial transplantations were performed. The gene discussed is CD7; the disease is acute lymphoblastic leukemia.