Mice transplanted with CD34+ enriched NOTCH1Mutated T-ALL cells (patients 03, 05, 08, 11) demonstrated significantly greater leukemic engraftment than mice transplanted with CD34− cells (Figures 1B and C; n = 79 mice, P = 0.0005, Student’s t-test). Here, CD34 is linked to acute lymphoblastic leukemia.