Following hN1 mAb treatment, immunohistochemical analyses revealed a marked increase in levels of activated caspase 3, and a concomitant reduction in levels of NOTCH1 in NOTCH1Mutated (patient 08) T-ALL LIC-engrafted bone marrow compared with control IgG1 mAb-treated control bone marrow (Figures 3A and B; **, P = 0.005; *, P<0.05, Student’s t test). The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.