Remarkably, compared to control mAb-treated animals transplanted with the bulk CD34+ population, in hN1 mAb-treated T-ALL LIC engrafted mice, there was a significant reduction in the CD34+CD2+CD7+ population, but not the CD34+CD2+CD7− population (Figure 5C). The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.