Following hN1 mAb treatment of NOTCH1Mutated T-ALL LIC-transplanted mice, FACS analysis revealed a significant reduction in leukemic CD34+ cell burden in both the marrow and spleen of hN1 mAb-treated mice (Figure 2C; **, P = 0.003 and Figure 2D, ***, P = 0.001, respectively, Wilcoxon test). The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.