USP15 and cardiac hypertrophy: No transcripts were consistently altered in all tissues, although ubiquitin specific peptidase 15 (USP15), a gene shown to induce cardiac hypertrophy in mice [43], showed an equivalent increase in expression in aorta and mammary artery tissues (aorta +1.16-fold per copy of the risk allele, p = 0.008; mammary artery +1.15-fold, p = 0.003).