Recent studies suggest that genetic variation within the 9p21.3 region may alter the expression of CDKN2B, CDKN2A, ANRIL (the large non-coding RNA that spans the CAD risk locus), and/or other genes on chromosome 9 located up to 1 Mb from the risk locus [35], [36], [37], [38], [39], [40]. The gene discussed is CDKN2A; the disease is coronary artery disorder.