Since a dysregulation in the production of proinflammatory cytokines also contributes to this inflammatory state through such factors as interleukin-6 (IL-6) and tumor necrosis factor –α (TNF-α) [11], determining the role of these cytokines in regulating immune lymphocyte responses in obesity is also essential in formulating treatments for obese individuals. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.