Here, we determine the role of Centchroman (CC)/Polyphenols alone plus polyphenols sensitized CC treated cells during stress signaling and intracellular redox status in vitro using the established Estrogen receptor (ER) positive (+ve) MCF-7 and negative (-ve) MDA MB-231 Human Breast Cancer Cells (HBCCs). Here, ESR1 is linked to breast carcinoma.