Recent studies revealed the important role of KLF15 as a central regulator of stress response and repressor of pathological cardiac hypertrophy and fibrosis by controlling factors such as GATA binding protein 4 (GATA4), myocyte enhancer factor-2 (MEF2), myocardin (Fisch et al, 2007; Leenders et al, 2010) and the transforming growth factor β (TGFβ) (Wang et al, 2008), respectively. Here, GATA4 is linked to hypertrophy.