For example, proteomic analysis of nasal epithelial cells from CF patients has demonstrated increased levels of BPIFA1 (Roxo-Rosa et al. 2006) and BPIFA1 and BPIFB1 are increased in sputum from patients with CF (McCray et al. 2005) and epithelial cells from CF patients express abundant BPIFA1 and BPIFB1 (Scheetz et al. 2004). The gene discussed is BPIFB1; the disease is cystic fibrosis.