NFATC2 and neoplasm: To a large part, the differences in oncogenic capacity between caNFATc1 and c2 could be attributed to the C-terminal peptide of NFATc2, since removal of the 230 aa long C-terminal peptide from NFATc2 (including its SUMO sites) released its tumor suppressor phenotype and “converted” NFATc2 to a NFATc1/αA-like protein [90].