LEP and Insulin resistance: BADGE administered orally at high doses to mice on a high-fat diet decreased triglyceride content in white adipose tissue, skeletal muscle, and the liver due to increased leptin (LEP) effects and increased fatty acid combustion and energy dissipation, thereby ameliorating high-fat diet–induced obesity and insulin resistance (Yamauchi et al. 2001; Yun et al. 2008).