One event is evidenced by significant discordant read pairs in the tumor mapping to the LINGO2 (leucine rich repeat and Ig domain containing 2) locus at 9q21.1 (chr9: 27990017-27991975), which is translocated to the TTC28 (tetratricopeptide repeat domain 28) locus at 22q12.1 (chr22: 27401302-27401562) (Figure 1). The gene discussed is LINGO2; the disease is neoplasm.