The most common were drugs for peptic ulcer or gastro-oesophageal reflux disease [12 (35.3%) in the pancreatin group and 10 (35.7%) in the placebo group]; insulin or insulin analogues [12 (35.3%) and 6 (21.4%), respectively]; blood glucose-lowering drugs other than insulin [9 (26.5%) and 6 (21.4%), respectively] and calcium [4 (11.8%) and 5 (17.9%), respectively]. This evidence concerns the gene INS and peptic ulcer disease.