TG2 plays an important role in mesenchymal tissue remodeling, where its function in cell adhesion, mesenchymal transition, and matrix stabilization not only are important in normal wound healing but also can be involved in disease states such as cancer, tissue fibrosis, celiac disease, neurodegeneration, and osteoarthritis [22,42,50-52]. Here, TGM2 is linked to osteoarthritis.