In addition, chronic administration of the 5-HT1 agonists was able to prevent the development of dyskinesia and upregulation of FosB expression in the striatum of 6-OHDA-lesioned rats [18], thus linking dysregulated DA release from serotonin terminals with the induction of a well-known striatal marker of dyskinesia. The gene discussed is FOSB; the disease is drug-induced dyskinesia.