Comparative real-time PCR analyses of MYC expression in CLBL-1, CLBL-1M, a non neoplastic lymph node sample, and DT08/40 (a canine prostate cancer cell line showing polysomy of CFA13) showed that -in contrast to DT08/40- both cell lines do not over-express MYC. CLBL-1 and CLBL-1M showed a statistical relevant down-regulation of MYC expression. This evidence concerns the gene MYC and Familial prostate cancer.