For human chronic lymphatic leukemia (CLL) and B-cell lymphoid neoplasms, the immunostimulatory CpG-oligonucleotide DSP30 in combination with interleukin-2 (IL-2) has been reported to be an easy and efficient stimulus for metaphase generation [33], [34], [35]. Here, IL2 is linked to B-cell chronic lymphocytic leukemia.