BRK1 and von Hippel-Lindau disease: C3orf10:VHL or BRK1:VHL (Table 1, #8) - VHL is a tumour suppressor gene deleted in von Hippel Lindau disease, an autosomal dominant familial cancer syndrome that can give rise to pheochromocytoma and tumours of the kidney, central nervous system, pancreas, retina and epididymis.