The authors showed that in human squamous carcinoma cells, AF1q downregulation was associated with a doxorubicine-resistant cell phenotype and that AF1q upmodulation caused an increased doxorubicin and γ radiation-induced apoptosis through transactivation of the proapoptotic protein BAD via NF-kB [24], [25]. The gene discussed is NFKB1; the disease is squamous cell carcinoma.