The recent findings that the AF1q gene, beside its documented oncogenic function [17]–[23], plays a role in apoptosis regulation in cancer cells [24], [25] and the fact that it has been described as an RA-target gene [14], prompted us to investigate its possible involvement in apoptosis induced by the synthetic nonclassic retinoid 4-HPR. This evidence concerns the gene MLLT11 and cancer.