Here we investigated whether the TrkB.T1 receptor isoform affects motoneuron survival and disease progression in a widely used ALS mouse model that carries a transgene with a human familiar Gly93→ALA mutation in the copper/zinc superoxide dismutase gene (SOD1G93A or SOD1 mice) [24], [25]. Here, NTRK2 is linked to amyotrophic lateral sclerosis.