Consistent with previous findings [4]–[14], recurrent gains including 11q13 (CCND1, EMS1), 3q26 (EIF5A2), 21q22 (ETS2 ) and 8q24 (MYC), and losses including 3p, 5q, 9p, 13q, 18q and 21q with target genes such as FHIT, APC, RB1 and CDKN2A, were identified in ESCC cell lines in this study. This evidence concerns the gene FHIT and esophageal squamous cell carcinoma.