In addition, TRIO and CTNND2 at 5p, MYC at 8q22, KLF5 and POU4F1 at 13q and NKX2.2 at 20p were also considered to play oncogenic roles in other tumors [35]; [36] and might contribute to ESCC carcinogenesis. The gene discussed is NKX2-2; the disease is esophageal squamous cell carcinoma.