CTNNB1 and hepatocellular carcinoma: In C57BL/129Sv×C3H/He mice, a strain more susceptible to hepatocarcinogenesis, DEN injection at around 6 weeks of age at a dose of 90 μg/gm body weight, induces HCC through Ha-Ras mutations, while inclusion of PB in drinking water after 3 weeks of DEN, promotes tumorigenesis due to CTNNB1 mutations.