As menin is a positive regulator of miR-24-1, while miR-24-1 negatively regulates the expression of menin, we conclude that menin and miR-24-1 form a “negative feedback loop” in the MEN1 parathyroid adenoma tissues without LOH (which thus still have one copy of the wild type allele). Here, MEN1 is linked to parathyroid gland adenoma.