Additionally, the non-tumor bearing skin of PDTC treated mice also exhibited decreases in the expression of downstream NFκB targets such as TRAIL, IL-1β, TNFα, and MnSOD as well as the inhibition of cell cycling proteins such as cyclin D1, cyclin E, PCNA, and BCL-2 thereby indicating a return to normal proliferation. This evidence concerns the gene TNF and neoplasm.