Similarly, lapatinib (1 μM), a dual tyrosine kinase inhibitor that interrupts HER2 and EGFR signaling pathways, reduced colony number by 47% (p<0.01) and prevented the reversal observed following co-infection with shEGFR-LV and pWPT-sTβRII (Fig. 6). Here, ERBB2 is linked to coinfection.