EGFR cross talk with multiple pathways is enhanced by the high frequency of Kras and Smad4 mutations, and by the abundance of TGF-β which alters the extracellular matrix in a manner that promotes cancer cell growth, induces aberrant epithelial-mesenchymal interactions, enhances angiogenesis, and promotes metastasis [4]–[7], [10], [13]–[14], [26]–[27]. Here, SMAD4 is linked to cancer.