In T3M4 cells, expression of pWPT-sTβRII was associated with decreased proliferation (40%, p<0.01) and angiogenesis (77%, p<0.01), expression of shEGFR-LV did not significantly alter proliferation but markedly decreased CD31 immunoreactivity (71%, p<0.01), whereas expression of both vectors markedly increased cancer cell proliferation (196%, p<0.01) in spite of a persistent decrease (85%, p<0.01) in CD31 immunoreactivity (Fig. 3A). Here, PECAM1 is linked to cancer.