KLF8 and hepatocellular carcinoma: Expression of KLF8 was detected in 25% (2/8) of Stage I HCC samples, 61.9% (13/21) of Stage II HCC samples, 84.61% (22/26) Stage III HCC samples, and 100% (10/10) Stage IV HCC samples (Fig. 1E), which showed expression of KLF8 positively correlates with progressed HCC.