Figure S1 shows that significant amplifications and deletions were spread in the whole genome. A restricted analysis of TF-encoding genes revealed that 2,113 of the 2,335 genes known to encode “DNA binding” proteins (GO term) had their loci significantly altered, at least, in one cell line. To select transcription factors relevant to cancer in a more stringent manner, we combined the analysis on expression, activity and CNV (Figure 1). The gene discussed is TF; the disease is cancer.