Below we discuss the potential involvement of our promising five novel biomarkers of hepatic fibrosis and the potential involvement of the following novel fibrosis biomarkers is shown in Table S3: apolipoprotein C-III, apolipoprotein E, hemopexin, alpha-1-antichymotrypsin (gene SERPINA3), alpha-1-antitrypsin (gene SERPINA1), C4b-binding protein beta chain. The gene discussed is HPX; the disease is Hepatic fibrosis.