Table 2 shows general pair-wise observations of tumor number and size for each CRC mouse model, ApcMin/+ and AOM. In addition to differential response observed between mouse models, we observe differences in response EGFR inhibitor AG1478 within each model according to strain (inbred vs F1). ApcMin/+ mice on the F1 genetic background had the most favorable overall response to AG1478 with a decrease in tumor number and size on both the STD and WD diets. The gene discussed is EGFR; the disease is infectious otitis media.