We found many candidate genes participated in specific KEGG pathways where known disease genes were over-represented and these two gene sets shared 60 (nearly 25%) common KEGG pathways such as cytokine-cytokine receptor interaction, Regulation of actin cytoskeleton, Focal adhesion, MAPK signaling pathway, Adipocytokine receptor signaling pathway, VEGF signaling pathway, Type I diabetes mellitus, hematopoietic cell lineage, and complement and coagulation cascades and so on (Table S2). Here, VEGFA is linked to type 1 diabetes mellitus.