FGFR signaling has pleiotropic effects on tumor development including (1) control of tumor growth, (2) promotion of tumor metastasis, (3) stimulation of tumor lymphangiogenesis, and (4) induction of VEGF-C and expression of VEGFRs or other pro-lymphangiogenic/survival factors in tumor cells and the lymphatic endothelium. Here, VEGFC is linked to neoplasm.