HMGCR and Familial prostate cancer: Changes in the expression levels of the key regulators of cholesterol homeostasis, namely sterol regulatory element binding transcription factors (SREBPs), HMGCR LDLR, acetyl-CoA acetyltransferase 1 (ACAT1) and scavenger receptor class B member 1 (SR-B1) have been shown to occur during the progression of prostate cancer from androgen-independent to castration-resistant cancer in an LNCaP xenograft model [14], [15].